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Systematic analysis to identify transcriptome-wide dysregulation of Alzheimer's disease in genes and isoforms.

Human genetics - 1 Apr 2021

Fan Cong, Chen Ken, Zhou Jiaxin, Wong Ping-Pui, He Dan, Huang Yiqi, Wang Xin, Ling Tianze, Yang Yuedong, Zhao Huiying

Abstract excerpt

Alzheimer's disease (AD) is one of the most common neurodegeneration diseases caused by multiple factors. The mechanistic insight of AD remains limited. To disclose molecular mechanisms of AD, many studies have been proposed from transcriptome analyses. However, no analysis across multiple levels of transcription has been conducted to discover co-expression networks of AD. We performed gene-level and...

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PMID: 33140241
DOI: 10.1007/s00439-020-02230-7

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