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Disturbed gut virome with potent interferonogenic property in systemic lupus erythematosus

18 Jan 2023

Abstract excerpt

Accumulating evidence suggests an essential role of disturbed gut microbiota in the etiopathogenesis of systemic lupus erythematosus (SLE), but it remains unclear as to gut virome. In this study, fecal virus-like particles (VLPs) isolated from 76 non-treated SLE patients and 75 healthy controls were subjected to gut virome profiling. The proportion of bacteriophages was significantly elevated in the SLE gut, and...

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PMID: 36697300
DOI: 10.1016/j.scib.2023.01.021

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