A Respiratory Syncytial Virus Attachment Gene Variant Associated with More Severe Disease in Infants Decreases Fusion Protein Expression, Which May Facilitate Immune Evasion.

doi:10.1128/JVI.01201-20

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Article

A Respiratory Syncytial Virus Attachment Gene Variant Associated with More Severe Disease in Infants Decreases Fusion Protein Expression, Which May Facilitate Immune Evasion.

Journal of virology - 22 Dec 2020

Human Stacey, Hotard Anne L, Rostad Christina A, Lee Sujin, McCormick Louise, Larkin Emma K, Peret Teresa C T, Jorba Jaume, Lanzone Joseph, Gebretsadik Tebeb, Williams John V, Bloodworth Melissa, Stier Matthew, Carroll Kecia, Peebles R Stokes, Anderson Larry J, Hartert Tina V, Moore Martin L

Abstract excerpt

This study identified a genotype of respiratory syncytial virus (RSV) associated with increased acute respiratory disease severity in a cohort of previously healthy term infants. The genotype (2stop+A4G) consists of two components. The A4G component is a prevalent point mutation in the 4th position of the gene end transcription termination signal of the G gene of currently circulating RSV strains. The 2stop...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33115881
DOI: 10.1128/JVI.01201-20
PMCID: PMC7944440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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