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Article

Predicting the protein composition of human urine in normal and pathological states: Quantitative description based on Dent1 disease (CLCN5 mutation).

The Journal of physiology - 1 Jan 2021

Edwards Aurélie, Christensen Erik I, Unwin Robert J, Norden Anthony G W

Abstract excerpt

KEY POINTS: The presence of plasma proteins in urine is difficult to interpret quantitatively. It may be a result of impaired glomerular filtration or impaired proximal tubule (PT) reabsorption, or both. Dent1 disease (CLCN5 mutation) abolishes PT protein reabsorption leaving glomerular function intact. Using urine protein measurements from patients with Dent1 disease and normal individuals, we devised a...

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PMID: 33107589
DOI: 10.1113/JP280740

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