Modeling of variables in cellular infection reveals CXCL10 levels are regulated by human genetic variation and the Chlamydia-encoded CPAF protease.

doi:10.1038/s41598-020-75129-y

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Article

Modeling of variables in cellular infection reveals CXCL10 levels are regulated by human genetic variation and the Chlamydia-encoded CPAF protease.

Scientific reports - 26 Oct 2020

Schott Benjamin H, Antonia Alejandro L, Wang Liuyang, Pittman Kelly J, Sixt Barbara S, Barnes Alyson B, Valdivia Raphael H, Ko Dennis C

Abstract excerpt

Susceptibility to infectious diseases is determined by a complex interaction between host and pathogen. For infections with the obligate intracellular bacterium Chlamydia trachomatis, variation in immune activation and disease presentation are regulated by both host genetic diversity and pathogen immune evasion. Previously, we discovered a single nucleotide polymorphism (rs2869462) associated with absolute...

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PMID: 33106516
DOI: 10.1038/s41598-020-75129-y
PMCID: PMC7588472

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