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Article

A large deletion on CFA28 omitting ACSL5 gene is associated with intestinal lipid malabsorption in the Australian Kelpie dog breed.

Scientific reports - 26 Oct 2020

O'Brien Mitchell J, Beijerink Niek J, Sansom Mandy, Thornton Sarah W, Chew Tracy, Wade Claire M

Abstract excerpt

Inborn errors of metabolism are genetic conditions that can disrupt intermediary metabolic pathways and cause defective absorption and metabolism of dietary nutrients. In an Australian Kelpie breeding population, 17 puppies presented with intestinal lipid malabsorption. Juvenile dogs exhibited stunted postnatal growth, steatorrhea, abdominal distension and a wiry coat. Using genome-wide association analysis, an...

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PMID: 33106515
DOI: 10.1038/s41598-020-75243-x
PMCID: PMC7589484

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