Article
Sequence Analysis of Six Candidate Genes in Miniature Schnauzers with Primary Hypertriglyceridemia.
Genes - 31 Jan 2024
Tate Nicole M, Underwood Michaela, Thomas-Hollands Alison, Minor Katie M, Cullen Jonah N, Friedenberg Steven G, Mickelson James R, Xenoulis Panagiotis G, Steiner Joerg M, Furrow Eva
Abstract excerpt
Miniature Schnauzers are predisposed to primary hypertriglyceridemia (HTG). In this study, we performed whole genome sequencing (WGS) of eight Miniature Schnauzers with primary HTG and screened for risk variants in six HTG candidate genes: LPL, APOC2, APOA5, GPIHBP1, LMF1, and APOE. Variants were filtered to identify those present in ≥2 Miniature Schnauzers with primary HTG and uncommon (<10% allele frequency) in...
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