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Article

Structural variation-driven FADS2P1 expression modulates hair trait diversity through unsaturated fatty acid metabolism in goats.

Journal of genetics and genomics = Yi chuan xue bao - 1 Aug 2026

Li Wenze, Lv Qi, Su Yixin, Liu Can, Jing Xianjin, Wu Yujiang, Wang Xin, Quan Guobo, Han Di, Li Chun, Badaoui Bouabid, Suo Langda, Gong Gao, Wang Na, Chen Oljibilig, Fan Yixing, He Jianning, Li Shaobin, Zhao Peng, Yan Xiaochun, Wang Ruijun, Zhang Yanjun, Li Jinquan, Wang Zhiying, Liu Yongbin, Su Rui

Abstract excerpt

Through natural and artificial selection, goats develop distinct hair phenotypes driven by genomic variations, such as structural variations (SVs). The fatty acid desaturase (FADS) family plays an important role in hair follicle (HF) growth, yet its molecular mechanisms remain unclear. In this study, we construct a goat graph-based pangenome containing 99,792 non-redundant presence-absence variations (PAVs) from...

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PMID: 41839314
DOI: 10.1016/j.jgg.2026.03.007

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