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B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation

22 Oct 2020

Abstract excerpt

Abstract Combined antiretroviral therapy (cART) for HIV-1 dramatically slows disease progression among HIV+individuals. Currently, lymphoma represents the main cause of death among HIV-1-infected patients. Detection of p17 variants (vp17s) endowed with B-cell clonogenic activity in HIV-1-seropositive patients with lymphoma suggests their possible role in lymphomagenesis. Here, we demonstrate that the clonogenic...

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PMID: 33093643
DOI: 10.1038/s41417-020-00246-9

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