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5‐FU inhibits migration and invasion of CRC cells through PI3K/AKT pathway regulated by MARCH1

21 Oct 2020

Abstract excerpt

Colorectal cancer is a major health problem with a significant impact on the patients' quality of life. 5-Fluorouracil is the most common chemotherapy drug used for this type of cancer. While its molecular mechanism is the inhibition of DNA synthesis via the inhibition of thymine nucleotide synthetase, its complete anticancer mechanism is not clear. Membrane-associated RING-CH-1 (MARCH1) is an E3 ubiquitin ligase...

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PMID: 33085122
DOI: 10.1002/cbin.11493

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