Article
AAT Phenotype Identification by Isoelectric Focusing.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Greene Dina N, Elliott-Jelf M C, Grenache David G
Abstract excerpt
Isoelectric focusing (IEF) electrophoresis is considered to be the gold standard test for determining an individual's AAT phenotype. IEF electrophoresis is a technique used to separate proteins by differences in their isoelectric point (pI). Testing is performed on serum that is applied to an agarose gel containing ampholytes which create a pH gradient ranging from 4.2 to 4.9. Variants of AAT are therefore...
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