Article
Platelet Glycoprotein Ib α-Chain as a Putative Therapeutic Target for Juvenile Idiopathic Arthritis: A Mendelian Randomization Study.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Apr 2021
Luo Shan, Clarke Sarah L N, Ramanan Athimalaipet V, Thompson Susan D, Langefeld Carl D, Marion Miranda C, Grom Alexei A, Schooling C Mary, Gaunt Tom R, Yeung Shiu Lun Au, Zheng Jie
Abstract excerpt
OBJECTIVE: To ascertain the role of platelet glycoprotein Ib α-chain (GPIbα) plasma protein levels in cardiovascular, autoimmune, and autoinflammatory diseases and whether its effects are mediated by platelet count. METHODS: We performed a two-sample Mendelian randomization (MR) study, using both a cis-acting protein quantitative trait locus (cis-pQTL) and trans-pQTL near the GP1BA and BRAP genes as instruments....
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