Article
Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2021
Satomi Kaishi, Ohno Makoto, Matsushita Yuko, Takahashi Masamichi, Miyakita Yasuji, Narita Yoshitaka, Ichimura Koichi, Yoshida Akihiko
Abstract excerpt
Homozygous deletion (HD) of CDKN2A is one of the most promising biomarkers for predicting poor prognosis of IDH-mutant diffuse gliomas. The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) recommendations propose that IDH-mutant lower-grade astrocytomas with CDKN2A/B HD be classified as grade IV tumors. Loss of methylthioadenosine phosphorylase (MTAP)...
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