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Article

Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity.

Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2020

Montgomery Theresa L, Künstner Axel, Kennedy Josephine J, Fang Qian, Asarian Lori, Culp-Hill Rachel, D'Alessandro Angelo, Teuscher Cory, Busch Hauke, Krementsov Dimitry N

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The etiology of MS is multifactorial, with disease risk determined by genetics and environmental factors. An emerging risk factor for immune-mediated diseases is an imbalance in the gut microbiome. However, the identity of gut microbes associated with disease risk, their mechanisms of action, and the interactions with host genetics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

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Source

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Identifiers

PMID: 33077601
DOI: 10.1073/pnas.2002817117
PMCID: PMC7959502

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