Article
Comparison of variant allele frequency and number of mutant molecules as units of measurement for circulating tumor DNA.
Molecular oncology - 1 Jan 2021
Bos Manouk K, Nasserinejad Kazem, Jansen Maurice P H M, Angus Lindsay, Atmodimedjo Peggy N, de Jonge Evert, Dinjens Winand N M, van Schaik Ron H N, Del Re Marzia, Dubbink Hendrikus J, Sleijfer Stefan, Martens John W M
Abstract excerpt
Quantification of tumor-specific variants (TSVs) in cell-free DNA is rapidly evolving as a prognostic and predictive tool in patients with cancer. Currently, both variant allele frequency (VAF) and number of mutant molecules per mL plasma are used as units of measurement to report those TSVs. However, it is unknown to what extent both units of measurement agree and what are the factors underlying an existing...
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