Article
Clinical and pathophysiological consequences of alterations in the microbiome in cirrhosis.
The American journal of gastroenterology - 1 Oct 2015
Macnaughtan Jane, Jalan Rajiv
Abstract excerpt
Cirrhosis is a major cause of mortality worldwide. Exponential rises in prevalence have been observed secondary to increases in obesity and alcohol consumption. Multiple lines of evidence implicate gut-derived bacteria and bacterial ligands as a central driver of pathogenesis. Recent developments in culture-independent techniques have facilitated a more accurate description of microbiome composition in cirrhosis...
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