Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours?

Molecular neurobiology - 1 Feb 2021

Banono Nancy Saana, Gawel Kinga, De Witte Linus, Esguerra Camila V

Abstract excerpt

Persons with certain single nucleotide polymorphisms (SNPs) in the CACNA1D gene (encoding voltage-gated calcium channel subunit alpha 1-D) have increased risk of developing neuropsychiatric disorders such as bipolar, schizophrenia and autism. The molecular consequences of SNPs on gene expression and protein function are not well understood. Thus, the use of animal models to determine genotype-phenotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channels, L-Type
Share to Darkness
Share to Electroencephalography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Activity

Share to Reflex, Startle

Share to RNA Splice Sites

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33057948
DOI: 10.1007/s12035-020-02160-5
PMCID: PMC7843589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours?PMID 33057948Read ↗

Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish.Semantic proximity Read ↗

Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome.Semantic proximity Read ↗

Elevated body temperature exacerbates arrhythmia and seizure-like activity in a zebrafish model of Timothy syndromeSemantic proximity Read ↗

Zebrafish as a tool to study schizophrenia-associated copy number variants.Semantic proximity Read ↗

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.Semantic proximity Read ↗

Causal Genetic Loci for a Motivated Behavior Spectrum Harbor Psychiatric Risk GenesSemantic proximity Read ↗

Behavioral Effects of Developmental Exposure to JWH-018 in Wild-Type and Disrupted in Schizophrenia 1 (disc1) Mutant Zebrafish.Semantic proximity Read ↗

A Zebrafish Platform to Model Human <i>SCN2A</i> and <i>SCN8A</i> Epilepsy and Evaluate Anti-Seizure MedicationsSemantic proximity Read ↗

Testing of putative antiseizure medications in a preclinical Dravet syndrome zebrafish modelSemantic proximity Read ↗

Orphan cytochrome P450 20A1 CRISPR/Cas 9 mutants and neurobehavioral phenotypes in zebrafishSemantic proximity Read ↗

<i>kcna1a</i> mutant zebrafish as a model of episodic ataxia type 1 and epilepsySemantic proximity Read ↗

Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.