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Article

The blood copper isotopic composition is a prognostic indicator of the hepatic injury in Wilson disease.

Metallomics : integrated biometal science - 1 Nov 2020

Lamboux Aline, Couchonnal-Bedoya Eduardo, Guillaud Olivier, Laurencin Chloé, Lion-François Laurence, Belmalih Abdelouahed, Mintz Elisabeth, Brun Virginie, Bost Muriel, Lachaux Alain, Balter Vincent

Abstract excerpt

Wilson disease (WD) is an autosomal recessive disorder of copper (Cu) metabolism. The gene responsible for WD, ATP7B, is involved in the cellular transport of Cu, and mutations in the ATP7B gene induce accumulation of Cu in the liver and ultimately in the brain. In a pilot study, the natural variations of copper stable isotope ratios (65Cu/63Cu) in the serum of WD patients have been shown to differ from that of...

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PMID: 33057522
DOI: 10.1039/d0mt00167h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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