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A Relationship between Endothelial Nitric Oxide Synthetase Gene Variants and Substance Use Disorder.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2021

Pehlivan Sacide, Aydin Pinar C, Nursal Ayse F, Pehlivan Mustafa, Oyaci Yasemin, Yazici Ahmet B

Abstract excerpt

BACKGROUND: Addictive substances are known to result in oxidative stress (OS). OS enhances the generation of free radicals and reactive oxygen species (ROS) and reduces antioxidant capacity. Peroxides and oxygen radicals, including hydrogen peroxide and superoxide and radical nitrogen species, including nitric oxide (NO), are parts of the ROS. Gene variants of the endothelial nitric oxide (eNOS) affect the plasma...

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PMID: 33050870
DOI: 10.2174/1871530320666201013154917

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