Article
Characterization of the mechanism of action of the genetically modified Cry1AbMod toxin that is active against Cry1Ab-resistant insects.
Biochimica et biophysica acta - 1 Oct 2009
Muñóz-Garay Carlos, Portugal Leivi, Pardo-López Liliana, Jiménez-Juárez Nuria, Arenas Ivan, Gómez Isabel, Sánchez-López Rosana, Arroyo Raquel, Holzenburg Andreas, Savva Christos G, Soberón Mario, Bravo Alejandra
Abstract excerpt
Bacillus thuringiensis Cry toxins are used in the control of insect pests. They are pore-forming toxins with a complex mechanism that involves the sequential interaction with receptors. They are produced as protoxins, which are activated by midgut proteases. Activated toxin binds to cadherin receptor, inducing an extra cleavage including helix alpha-1, facilitating the formation of a pre-pore oligomer. The toxin...
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