Article
Pathogenic mutations reveal a role of RECQ4 in mitochondrial RNA:DNA hybrid formation and resolution.
Scientific reports - 12 Oct 2020
Chang Chou-Wei, Xu Xiaohua, Li Min, Xin Di, Ding Lin, Wang Ya-Ting, Liu Yilun
Abstract excerpt
The synthesis of mitochondrial DNA (mtDNA) is a complex process that involves the formation and resolution of unusual nucleic acid structures, such as RNA:DNA hybrids. However, little is known about the enzymes that regulate these processes. RECQ4 is a DNA replication factor important for mtDNA maintenance, and here, we unveil a role of human RECQ4 in regulating the formation and resolution of mitochondrial...
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