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A quantitative approach relating emergent features of complex traits to protein expression.

Progress in biophysics and molecular biology - 1 May 2021

Wegner Lars H, Hao Zhifeng

Abstract excerpt

Linking complex, multigenic traits to protein activity is an important challenge in current biology, including applications in the medical sciences, agriculture, or forestry. Two simple algorithms are presented here to establish that link. The first one describes synergistic interactions of n proteins in shaping a complex trait ('weak emergence') as opposed to a simply additive 'modular' contribution of these...

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PMID: 33035591
DOI: 10.1016/j.pbiomolbio.2020.10.002

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