Article
Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study.
Molecular cancer therapeutics - 1 Dec 2020
Werfel Thomas A, Hicks Donna J, Rahman Bushra, Bendeman Wendy E, Duvernay Matthew T, Maeng Jae G, Hamm Heidi, Lavieri Robert R, Joly Meghan M, Pulley Jill M, Elion David L, Brantley-Sieders Dana M, Cook Rebecca S
Abstract excerpt
Although new drug discoveries are revolutionizing cancer treatments, repurposing existing drugs would accelerate the timeline and lower the cost for bringing treatments to cancer patients. Our goal was to repurpose CPI211, a potent and selective antagonist of the thromboxane A2-prostanoid receptor (TPr), a G-protein-coupled receptor that regulates coagulation, blood pressure, and cardiovascular homeostasis. To...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.