Article
Altered Yersinia pestis virulence is associated with the small regulatory RNA HmsA encoded on the plasmid pPCP1.
Future microbiology - 1 Sept 2020
Gao Xiaofang, Wang Min, Liu Zizhong, Bi Yujing, Song Yajun, Yang Ruifu, Han Yanping
Abstract excerpt
Aim: The aim of this study was to access the effect of HmsA, a 65-nt small regulatory RNA encoded by the pPCP1 plasmid, on Yersinia pestis virulence. Materials & methods: Survival and the competition index were determined in mice infected with wild-type Y. pestis and an hmsA deletion mutant. RNA-seq was used to identify HmsA-regulated genes. Results: HmsA deletion enhanced Y. pestis virulence. However, there was...
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