Article
Genetic variants implicated in telomere length associated with left ventricular function in patients with hypertension and cardiac organ damage.
Journal of molecular medicine (Berlin, Germany) - 1 Sept 2012
Huber Matthias, Treszl Andras, Wehland Markus, Winther Ingke, Zergibel Irina, Reibis Rona, Bolbrinker Juliane, Stoll Monika, Schönfelder Gilbert, Wegscheider Karl, Völler Heinz, Kreutz Reinhold
Abstract excerpt
Telomere length has emerged as a biological correlate for ageing, which in turn is a risk factor for the manifestation of cardiovascular diseases. This study investigated the relation between leucocyte telomere length (LTL) and its genetic background to cardiac structure and function in patients with arterial hypertension. We analysed a cohort of 1,106 treated hypertensive patients (83.3% males; mean age,...
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