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Article

KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells.

Acta pharmacologica Sinica - 1 Apr 2019

Qi Xiao-Tian, Li Yang-Ling, Zhang Yan-Qi, Xu Tong, Lu Bin, Fang Liang, Gao Jian-Qing, Yu Lu-Shan, Zhu Di-Feng, Yang Bo, He Qiao-Jun, Ying Mei-Dan

Abstract excerpt

Despite more effective chemotherapy combined with limb-salvage surgery for the osteosarcoma treatment, survival rates for osteosarcoma patients have stagnated over the past three decades due to the poor prognosis. Osteosarcoma cancer stem cells (OSCs) are responsible for the growth and metastasis of osteosarcoma. The existence of OSCs offers a theoretical explanation for therapeutic failures including tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Factor 4

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Source

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Identifiers

PMID: 29930276
DOI: 10.1038/s41401-018-0050-6
PMCID: PMC6461873

Genes

KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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