Article
An Investigation of Fibulin-2 in Hypertrophic Cardiomyopathy.
International journal of molecular sciences - 29 Sept 2020
Ibrahim Ayman M, Roshdy Mohamed, Elshorbagy Sara, Hosny Mohammed, Halawa Sarah, Yehia Dina, Elfawy Hasnaa A, Eldessouki Ahmed, Mohamed Faisal, Ellithy Amany, Abdelfattah Mohamed, Elsawy Amr, Elkhatib Mohamed, Allouba Mona, Elguindy Ahmed, Aguib Yasmine, Yacoub Magdi
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart muscle disease, with a prevalence of at least 1 in 500 in the general population. The disease is pleiotropic and is characterized by an increased stiffness of the myocardium, partly due to changes in the extracellular matrix (ECM), with elevated levels of interstitial fibrosis. Myocardial fibrosis is linked to impaired diastolic function and...
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