Article
T follicular helper phenotype predicts response to histone deacetylase inhibitors in relapsed/refractory peripheral T-cell lymphoma.
Blood advances - 13 Oct 2020
Ghione Paola, Faruque Promie, Mehta-Shah Neha, Seshan Venkatraman, Ozkaya Neval, Bhaskar Shakthi, Yeung James, Spinner Michael A, Lunning Matthew, Inghirami Giorgio, Moskowitz Alison, Galasso Natasha, Ganesan Nivetha, van der Weyden Carrie, Ruan Jia, Prince H Miles, Trotman Judith, Advani Ranjana, Dogan Ahmet, Horwitz Steven
Abstract excerpt
Histone deacetylase inhibitors (HDACi) are active agents for peripheral T-cell lymphoma (PTCL). Anecdotally angioimmunoblastic T-cell lymphoma (AITL) appears to respond better than PTCL-not otherwise specified (NOS) to HDACi. The new World Health Organization classification shows that a subgroup of PTCL carries similarities in phenotype and gene expression profiling to AITL, comparable to T follicular helper...
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