Two Sides of a Coin: a Zika Virus Mutation Selected in Pregnant Rhesus Macaques Promotes Fetal Infection in Mice but at a Cost of Reduced Fitness in Nonpregnant Macaques and Diminished Transmissibility by Vectors.

doi:10.1128/JVI.01605-20

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Two Sides of a Coin: a Zika Virus Mutation Selected in Pregnant Rhesus Macaques Promotes Fetal Infection in Mice but at a Cost of Reduced Fitness in Nonpregnant Macaques and Diminished Transmissibility by Vectors.

Journal of virology - 23 Nov 2020

Lemos Danilo, Stuart Jackson B, Louie William, Singapuri Anil, Ramírez Ana L, Watanabe Jennifer, Usachenko Jodie, Keesler Rebekah I, Sanchez-San Martin Claudia, Li Tony, Martyn Calla, Oliveira Glenn, Saraf Sharada, Grubaugh Nathan D, Andersen Kristian G, Thissen James, Allen Jonathan, Borucki Monica, Tsetsarkin Konstantin A, Pletnev Alexander G, Chiu Charles Y, Van Rompay Koen K A, Coffey Lark L

Abstract excerpt

Although fetal death is now understood to be a severe outcome of congenital Zika syndrome, the role of viral genetics is still unclear. We sequenced Zika virus (ZIKV) from a rhesus macaque fetus that died after inoculation and identified a single intrahost substitution, M1404I, in the ZIKV polyprotein, located in nonstructural protein 2B (NS2B). Targeted sequencing flanking position 1404 in 9 additional macaque...

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PMID: 32999034
DOI: 10.1128/JVI.01605-20
PMCID: PMC7925200

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