Article
Update on Genetic Basis of Brugada Syndrome: Monogenic, Polygenic or Oligogenic?
International journal of molecular sciences - 28 Sept 2020
Campuzano Oscar, Sarquella-Brugada Georgia, Cesar Sergi, Arbelo Elena, Brugada Josep, Brugada Ramon
Abstract excerpt
Brugada syndrome is a rare inherited arrhythmogenic disease leading to ventricular fibrillation and high risk of sudden death. In 1998, this syndrome was linked with a genetic variant with an autosomal dominant pattern of inheritance. To date, rare variants identified in more than 40 genes have been potentially associated with this disease. Variants in regulatory regions, combinations of common variants and other...
Topics
- Alleles
- Brugada Syndrome
- Death, Sudden, Cardiac
- Electrocardiography
- Gene Expression
- Gene Frequency
- Genes, Dominant
- Genetic Predisposition to Disease
- Genetic Testing
- Humans
- Multifactorial Inheritance
- Mutation
- NAV1.5 Voltage-Gated Sodium Channel
- Phenotype