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Article

Whole exome sequencing identifies rare coding variants in novel human-mouse ortholog genes in African individuals diagnosed with non-syndromic hearing impairment.

Experimental biology and medicine (Maywood, N.J.) - 1 Jan 2021

Oluwole Oluwafemi G, Esoh Kevin K, Wonkam-Tingang Edmond, Manyisa Noluthando, Noubiap Jean Jacques, Chimusa Emile R, Wonkam Ambroise

Abstract excerpt

Physiologically, the human and murine hearing systems are very similar, justifying the extensive use of mice in experimental models for hearing impairment (HI). About 340 murine HI genes have been reported; however, whether variants in all human-mouse ortholog genes contribute to HI has been rarely investigated. In humans, nearly 120 HI genes have been identified to date, with GJB2 and GJB6 variants accounting...

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PMID: 32996353
DOI: 10.1177/1535370220960388
PMCID: PMC7871117

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