Article
Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study.
Adipocyte - 1 Dec 2020
Rodriguez-Ayala Ernesto, Gallegos-Cabrales Esther C, Gonzalez-Lopez Laura, Laviada-Molina Hugo A, Salinas-Osornio Rocio A, Nava-Gonzalez Edna J, Leal-Berumen Irene, Escudero-Lourdes Claudia, Escalante-Araiza Fabiola, Buenfil-Rello Fatima A, Peschard Vanessa-Giselle, Laviada-Nagel Antonio, Silva Eliud, Veloz-Garza Rosa A, Martinez-Hernandez Angelica, Barajas-Olmos Francisco M, Molina-Segui Fernanda, Gonzalez-Ramirez Lucia, Espadas-Olivera Rebeca, Lopez-Muñoz Ricardo, Arjona-Villicaña Ruy D, Hernandez-Escalante Victor M, Rodriguez-Arellano Martha E, Gaytan-Saucedo Janeth F, Vaquera Zoila, Acebo-Martinez Monica, Cornejo-Barrera Judith, Huertas-Quintero Jancy Andrea, Castillo-Pineda Juan Carlos, Murillo-Ramirez Areli, Diaz-Tena Sara P, Figueroa-Nuñez Benigno, Valencia-Rendon Melesio E, Garzon-Zamora Rafael, Viveros-Paredes Juan Manuel, Ángeles-Chimal José, Santa-Olalla Tapia Jesús, Remes-Troche José M, Valdovinos-Chavez Salvador B, Huerta-Avila Eira E, Lopez-Alvarenga Juan Carlos, Comuzzie Anthony G, Haack Karin, Han Xianlin, Orozco Lorena, Weintraub Susan, Kent Jack W, Cole Shelley A, Bastarrachea Raul A
Abstract excerpt
Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin...
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