Article
Variants of WNT7A and GPR124 are associated with hemorrhagic transformation following intravenous thrombolysis in ischemic stroke.
CNS neuroscience & therapeutics - 1 Jan 2021
Ta Song, Rong Xianfang, Guo Zhen-Ni, Jin Hang, Zhang Peng, Li Fenge, Li Zhihuan, Lin Lilong, Zheng Chenqing, Gu Qingquan, Zhang Yuan, Liu Wenlan, Yang Yi, Chang Junlei
Abstract excerpt
AIMS: The canonical Wnt signaling pathway plays an essential role in blood-brain barrier integrity and intracerebral hemorrhage in preclinical stroke models. Here, we sought to explore the association between canonical Wnt signaling and hemorrhagic transformation (HT) following intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients as well as to determine the underlying cellular mechanisms....
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