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Article

Whole-exome sequencing of 79 xenografts as a potential approach for the identification of genetic variants associated with sensitivity to cytotoxic anticancer drugs.

PloS one - 1 Jan 2020

Udagawa Chihiro, Sasaki Yasushi, Tanizawa Yasuhiro, Suemizu Hiroshi, Ohnishi Yasuyuki, Nakamura Yasukazu, Tokino Takashi, Zembutsu Hitoshi

Abstract excerpt

Chemotherapy response remains unpredictable in most patients with cancer. In this study, we performed whole-exome sequencing of 79 cancer xenografts derived from human cancer tissues to identify genetic predictors of chemosensitivity to nine cytotoxic anticancer drugs. Xenografts were harvested from 12 organs with cancer and implanted into nude mice. The mice were exposed to one of nine cytotoxic anticancer drugs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32986753
DOI: 10.1371/journal.pone.0239614
PMCID: PMC7521756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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