Article
Characterization of BRAF mutation in patients older than 45 years with well-differentiated thyroid carcinoma.
Brazilian journal of otorhinolaryngology - 1 Jan 2000
Barreno Luis Rene Quiroa, Mello Julia Bette Homem de, Barros-Filho Mateus Camargo, Francisco Ana Lucia, Chulam Thiago Celestino, Pinto Clovis Antonio Lopes, Gonçalves-Filho Joao, Kowalski Luiz Paulo
Abstract excerpt
INTRODUCTION: Papillary thyroid carcinoma is the most frequent endocrine neoplasia and its incidence has tripled over the past 35 years. Although papillary thyroid carcinoma carries a good prognosis, 10%-30% of patients still develop recurrence and metastasis. Some clinical and genetic features are associated with worse prognosis. The most frequent mutation is the BRAF p.V600E, which has been associated with many...
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