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Stepwise differentiation and functional characterization of human induced pluripotent stem cell-derived choroidal endothelial cells

23 Sept 2020

Abstract excerpt

BACKGROUND: Endothelial cells (ECs) are essential regulators of the vasculature, lining arteries, veins, and capillary beds. While all ECs share a number of structural and molecular features, heterogeneity exists depending on their resident tissue. ECs lining the choriocapillaris in the human eye are lost early in the pathogenesis of age-related macular degeneration (AMD), a common and devastating form of vision...

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PMID: 32967716
DOI: 10.1186/s13287-020-01903-4

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