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Article

Possible Role of the RORC Gene in Primary and Secondary Lymphedema: Review of the Literature and Genetic Study of Two Rare Causative Variants.

Lymphatic research and biology - 1 Apr 2021

Michelini Sandro, Ricci Maurizio, Serrani Roberta, Stuppia Liborio, Beccari Tommaso, Veselenyiova Dominika, Kenanoglu Sercan, Barati Shila, Kurti Danjela, Baglivo Mirko, Basha Syed Hussain, Krajcovic Juraj, Dundar Munis, Bertelli Matteo

Abstract excerpt

Background: RAR-related Orphan Receptor C (RORC) is a DNA-binding transcription factor and the key transcription factor responsible for differentiation of T helper 17 cells. The RORC gene plays a role in lymphoid organogenesis, thymopoiesis, and lymph node organogenesis. The aim of our study was to determine the possible role of RORC in the development of lymphatic system malformations by combining data from the...

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Identifiers

PMID: 32960152
DOI: 10.1089/lrb.2020.0030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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