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CXCL5‐CXCR2 signaling is a senescence‐associated secretory phenotype in preimplantation embryos

22 Sept 2020

Abstract excerpt

Pregnancy rate of women decreases with age due to declining quality of oocytes and embryos. However, there is no established method to improve pregnancy rate in aging women. In this study, we identified a senescence-associated secretory phenotype (SASP) factor partially responsible for the decline in embryo implantation potential. Based on microarray analysis using young and aging human embryos at the same...

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PMID: 32959976
DOI: 10.1111/acel.13240

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