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Identification of genomic alterations and associated transcriptomic profiling reveal the prognostic significance of MMP14 and PKM2 in patients with pancreatic cancer

17 Sept 2020

Abstract excerpt

Pancreatic cancer is characterized by multiple genomic alterations, including KRAS mutations, TP53 mutations and CDKN2A deletion. However, the prognostic relevance of those genomic alterations and associated transcriptomic profiling in pancreatic cancer are unclear. Integrated analysis of The Cancer Genome Atlas (TCGA) datasets revealed that KRAS mutation, TP53 mutation and CDKN2A deletion were all bad prognostic...

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PMID: 32950968
DOI: 10.18632/aging.103958

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