RAS as a positive predictive biomarker: focus on lung and colorectal cancer patients.

doi:10.1016/j.ejca.2021.01.015

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Article

RAS as a positive predictive biomarker: focus on lung and colorectal cancer patients.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2021

Malapelle Umberto, Passiglia Francesco, Cremolini Chiara, Reale Maria Lucia, Pepe Francesco, Pisapia Pasquale, Avallone Antonio, Cortinovis Diego, De Stefano Alfonso, Fassan Matteo, Fontanini Gabriella, Galetta Domenico, Lauricella Calogero, Listì Angela, Loupakis Fotios, Pagni Fabio, Pietrantonio Filippo, Pilotto Sara, Righi Luisella, Bianchi Andrea Sartore, Parra Hector Soto, Tiseo Marcello, Verzè Michela, Troncone Giancarlo, Novello Silvia

Abstract excerpt

Rat sarcoma (RAS) oncogenes have intensively been investigated during the last decades. Taking into account all human tumours, Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) gene is the most frequently mutated (about 22%) among the three isoforms, followed by Neuroblastoma RAS Viral Oncogene Homolog (NRAS) (8%) and Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS) (3%). In the last years, careful attention has...

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PMID: 33588147
DOI: 10.1016/j.ejca.2021.01.015

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