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Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells

18 Sept 2020

Abstract excerpt

Pathway analysis is an informative method for comparing and contrasting drug-induced gene expression in cellular systems. Here, we define the effects of the marine natural product fucoxanthin, separately and in combination with the prototypic phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002, on gene expression in a well-established human glioblastoma cell system, U87MG. Under conditions which inhibit cell...

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PMID: 32946518
DOI: 10.1371/journal.pone.0239551

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