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Transcriptional Analysis of MexAB-OprM Efflux Pumps System of Pseudomonas aeruginosa and Its Role in Carbapenem Resistance in a Tertiary Referral Hospital in India.

PloS one - 1 Jan 2015

Choudhury Debarati, Das Talukdar Anupam, Dutta Choudhury Manabendra, Maurya Anand Prakash, Paul Deepjyoti, Dhar Chanda Debadatta, Chakravorty Atanu, Bhattacharjee Amitabha

Abstract excerpt

Carbapenem resistance presents severe threat to the treatment of multidrug resistant Pseudomonas aeruginosa infections. The study was undertaken to investigate the role of efflux pumps in conferring meropenem resistance and effect of single dose exposure of meropenem on transcription level of mexA gene in clinical isolates of P. aeruginosa from a tertiary referral hospital of India. Further, in this investigation...

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PMID: 26221722
DOI: 10.1371/journal.pone.0133842
PMCID: PMC4519154

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Source receipt: pubmed, retrieved 7 Sept 2026.

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