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Plasmodium vivax Strains Use Alternative Pathways for Invasion

16 Sept 2020

Abstract excerpt

Plasmodium vivax has 2 invasion ligand/host receptor pathways (P. vivax Duffy-binding protein/Duffy antigen receptor for chemokines [DARC] and P. vivax reticulocyte binding protein 2b/transferrin receptor [TfR1]) that are promising targets for therapeutic intervention. We optimized invasion assays with isogenic cultured reticulocytes. Using a receptor blockade approach with multiple P. vivax isolates, we found...

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PMID: 32941614
DOI: 10.1093/infdis/jiaa592

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