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Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16

17 Sept 2020

Abstract excerpt

To investigate the characteristics and molecular events of dental pulp stem cells (DPSCs) for tissue regeneration with aging, we isolated and analyzed the stem cells from human exfoliated deciduous teeth (SHED) and permanent teeth of young (Y-DPSCs) and old (A-DPSCs) adults. Results showed that the stemness and osteogenic differentiation capacity of DPSCs decreased with aging. The RNA sequencing results showed...

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PMID: 32940141
DOI: 10.1177/0022034520958374

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