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Article

Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450.

The Journal of biological chemistry - 24 Apr 2009

Hamdane Djemel, Xia Chuanwu, Im Sang-Choul, Zhang Haoming, Kim Jung-Ja P, Waskell Lucy

Abstract excerpt

NADPH-cytochrome P450 oxidoreductase (CYPOR) catalyzes the transfer of electrons to all known microsomal cytochromes P450. A CYPOR variant, with a 4-amino acid deletion in the hinge connecting the FMN domain to the rest of the protein, has been crystallized in three remarkably extended conformations. The variant donates an electron to cytochrome P450 at the same rate as the wild-type, when provided with...

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Identifiers

PMID: 19171935
DOI: 10.1074/jbc.M807868200
PMCID: PMC2670143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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