Article
Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A.
The American journal of clinical nutrition - 11 Nov 2020
Lai Chao-Qiang, Parnell Laurence D, Smith Caren E, Guo Tao, Sayols-Baixeras Sergi, Aslibekyan Stella, Tiwari Hemant K, Irvin Marguerite R, Bender Carl, Fei David, Hidalgo Bertha, Hopkins Paul N, Absher Devin M, Province Michael A, Elosua Roberto, Arnett Donna K, Ordovas Jose M
Abstract excerpt
BACKGROUND: Epigenome-wide association studies identified the cg00574958 DNA methylation site at the carnitine palmitoyltransferase-1A (CPT1A) gene to be associated with reduced risk of metabolic diseases (hypertriglyceridemia, obesity, type 2 diabetes, hypertension, metabolic syndrome), but the mechanism underlying these associations is unknown. OBJECTIVES: We aimed to elucidate whether carbohydrate and fat...
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