Article
Data-Driven Modeling of Knowledge Assemblies in Understanding Comorbidity Between Type 2 Diabetes Mellitus and Alzheimer's Disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2020
Karki Reagon, Madan Sumit, Gadiya Yojana, Domingo-Fernández Daniel, Kodamullil Alpha Tom, Hofmann-Apitius Martin
Abstract excerpt
BACKGROUND: Recent studies have suggested comorbid association between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) through identification of shared molecular mechanisms. However, the inference is pre-dominantly literature-based and lacks interpretation of pre-disposed genomic variants and transcriptomic measurables. OBJECTIVE: In this study, we aim to identify shared genetic variants and...
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