Article
Association of common genetic variants with brain microbleeds: A genome-wide association study.
Neurology - 15 Dec 2020
Knol Maria J, Lu Dongwei, Traylor Matthew, Adams Hieab H H, Romero José Rafael J, Smith Albert V, Fornage Myriam, Hofer Edith, Liu Junfeng, Hostettler Isabel C, Luciano Michelle, Trompet Stella, Giese Anne-Katrin, Hilal Saima, van den Akker Erik B, Vojinovic Dina, Li Shuo, Sigurdsson Sigurdur, van der Lee Sven J, Jack Clifford R, Wilson Duncan, Yilmaz Pinar, Satizabal Claudia L, Liewald David C M, van der Grond Jeroen, Chen Christopher, Saba Yasaman, van der Lugt Aad, Bastin Mark E, Windham B Gwen, Cheng Ching Yu, Pirpamer Lukas, Kantarci Kejal, Himali Jayandra J, Yang Qiong, Morris Zoe, Beiser Alexa S, Tozer Daniel J, Vernooij Meike W, Amin Najaf, Beekman Marian, Koh Jia Yu, Stott David J, Houlden Henry, Schmidt Reinhold, Gottesman Rebecca F, MacKinnon Andrew D, DeCarli Charles, Gudnason Vilmundur, Deary Ian J, van Duijn Cornelia M, Slagboom P Eline, Wong Tien Yin, Rost Natalia S, Jukema J Wouter, Mosley Thomas H, Werring David J, Schmidt Helena, Wardlaw Joanna M, Ikram M Arfan, Seshadri Sudha, Launer Lenore J, Markus Hugh S
Abstract excerpt
OBJECTIVE: To identify common genetic variants associated with the presence of brain microbleeds (BMBs). METHODS: We performed genome-wide association studies in 11 population-based cohort studies and 3 case-control or case-only stroke cohorts. Genotypes were imputed to the Haplotype Reference Consortium or 1000 Genomes reference panel. BMBs were rated on susceptibility-weighted or T2*-weighted gradient echo MRI...
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