Article
Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains.
Genome biology - 1 Jan 2007
Rohmer Laurence, Fong Christine, Abmayr Simone, Wasnick Michael, Larson Freeman Theodore J, Radey Matthew, Guina Tina, Svensson Kerstin, Hayden Hillary S, Jacobs Michael, Gallagher Larry A, Manoil Colin, Ernst Robert K, Drees Becky, Buckley Danielle, Haugen Eric, Bovee Donald, Zhou Yang, Chang Jean, Levy Ruth, Lim Regina, Gillett Will, Guenthener Don, Kang Allison, Shaffer Scott A, Taylor Greg, Chen Jinzhi, Gallis Byron, D'Argenio David A, Forsman Mats, Olson Maynard V, Goodlett David R, Kaul Rajinder, Miller Samuel I, Brittnacher Mitchell J
Abstract excerpt
BACKGROUND: Francisella tularensis subspecies tularensis and holarctica are pathogenic to humans, whereas the two other subspecies, novicida and mediasiatica, rarely cause disease. To uncover the factors that allow subspecies tularensis and holarctica to be pathogenic to humans, we compared their genome sequences with the genome sequence of Francisella tularensis subspecies novicida U112, which is nonpathogenic...
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