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Article

Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model.

Scientific reports - 8 Sept 2020

Fernandez-Valenzuela Juan Jose, Sanchez-Varo Raquel, Muñoz-Castro Clara, De Castro Vanessa, Sanchez-Mejias Elisabeth, Navarro Victoria, Jimenez Sebastian, Nuñez-Diaz Cristina, Gomez-Arboledas Angela, Moreno-Gonzalez Ines, Vizuete Marisa, Davila Jose Carlos, Vitorica Javier, Gutierrez Antonia

Abstract excerpt

In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation of hyperphosphorylated tau leading to neurofibrillary pathology. AD brains also accumulate amyloid-beta (Aβ) deposits. However, the effect of microtubule stabilizing agents on Aβ pathology has...

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Identifiers

PMID: 32901091
DOI: 10.1038/s41598-020-71767-4
PMCID: PMC7479116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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